Every year, hundreds of thousands of men are diagnosed with cancers specific to men. The good news is that these cancers are treatable, if found early. However, many men hesitate to be screened for these cancers because of traditional male stereotypes and a fear that, if diagnosed, a surgical treatment will be necessary.

The specialists at MedStar Health encourage men to be screened, as a diagnosis of testicular cancer does not automatically mean surgery—depending on the stage of the cancer, a number of options can be explored. And, should you be diagnosed with cancer, our teams will be with you each step of the way, give you the most advanced compassionate care available.


Testicular cancer is a relatively rare, but highly curable, disease. Though it accounts for only one percent of all cancer in men, testicular cancer is the most common cancer in young men between the ages of 15 and 35. It is also more common in Caucasian men than in African American, Asian, or Hispanic men.

The two main classifications of testicular cancer are:

  1. Seminomas: Pure seminomas account for about 40 percent of all testicular cancer and are made up of immature sperm-forming cells called germ cells. Usually, seminomas are slow-growing and stay localized in the testicle for long periods.
  2. Nonseminomas: Nonseminomas arise from more mature, specialized germs cells than seminomas, and they tend to be more aggressive. Nonseminomas are a group of cancers that often occur in combination with one another, including choriocarcinoma, embryonal carcinoma, immature teratoma, and yolk sac tumors.


No one really knows what causes testicular cancer. Research has shown that some men are more likely than others to develop it. A man who has previously had testicular cancer is at increased risk of developing cancer in the other testicle. Research has also shown that testicular cancer is sometimes linked to certain other rare conditions in which the testicles do not develop normally, including:

  • Undescended testicle or cryptorchidism (a testicle that has never moved down into the scrotum): Men who have undescended testicles are at higher risk of developing cancer of the testicle than other men whose testicles have moved down into the scrotum, even if they have had surgery to correct this.
  • Klinefelter's syndrome: Men with Klinefelter's syndrome (a sex chromosome disorder characterized by low levels of male hormones, sterility, breast enlargement, and small testes) are at greater risk of developing testicular cancer.

Testicular Self-Exam

If you're a man between the ages of 15 and 40, this monthly self-exam of your testicles can help detect testicular cancer at an early—and curable—stage. It is simple to do and takes only a few minutes.

  • Take a warm bath or shower to relax the scrotum. This makes it easier to spot anything abnormal.
  • Stand naked in front of a mirror.
  • Check the skin of your scrotum for swelling.
  • Feel the right testicle within your scrotal sac.
  • With your index and middle fingers under the testicle, thumbs placed on top, roll the testicle between the thumbs and fingers.
  • Find the epididymis, the soft, cordlike structure behind the testicle that collects and carries sperm. (Do not confuse the epididymis with a lump. Cancerous lumps usually are found on the sides of the testicle, but can also show up on the front. Lumps on the epididymis are not cancerous.)
  • Feel for a lump on the surface of the testicle.
  • Repeat with the left testicle.

If you find a lump or swelling, see your doctor right away. The abnormality may not be cancer; it may be an infection. But if it is testicular cancer, it will spread if untreated.


Most testicular cancers are found by men themselves. Doctors generally examine the testicles during routine physical exams; however, men should perform a testicular self-exam regularly and report any changes to their doctor. Symptoms of testicular cancer and other conditions are often similar, making it very important to see a doctor, preferably a urologist, if you have the following:

  • A painless lump or swelling in either testicle
  • Any enlargement of a testicle or change in the way it feels
  • A feeling of heaviness in the scrotum
  • A significant shrinking of a testicle
  • A dull ache in the lower abdomen or in the groin
  • A sudden collection of fluid in the scrotum
  • Pain or discomfort in a testicle or in the scrotum

At MedStar Health, we use several tests to diagnosis testicular cancer including:

  • Abdominal CT scan
  • Blood tests for tumor markers: alpha fetoprotein (AFP), human chronic gonadotrophin (beta HCG), and lactic dehydrogenase (LDH)
  • Chest X-ray
  • Ultrasound of the scrotum


If found early, testicular cancer is almost always curable. Treatment at MedStar Health depends on the type and stage of the cancer, the patient's age and general health, and other factors.

There are essentially three types of treatment, which may be used alone or in combination:


Surgery is the most common treatment for most stages of cancer of the testicle. A doctor may take out the cancer by removing one or both testicles. Also, surgery may be needed to remove the lymph nodes into which the testicles drain. (Surgical removal of lymph nodes usually is not necessary for patients with seminomas, which are slow growing and tend to stay localized.)

In the past, everyone with testicular cancer had some additional treatment beyond surgery. However, researchers have a better understanding of how the disease spreads and how to treat it. For instance, men whose cancer is stage one (confined to the testes) may not need any further treatment. For these patients, waiting and watching with regular testing is a reasonable option.

Men who opt to watch and wait must undergo regular testing, which may include regular chest X-rays, blood tests to measure tumor marker levels, physical exams, and abdominal CT scans.

Radiation Therapy

In radiation therapy, X-rays or other high-energy rays are used to kill cancer cells and shrink tumors. Like surgery, radiation therapy is a local treatment and affects only the cells in the treated area. Radiation therapy is usually done on an outpatient basis.

Seminomas are highly sensitive to radiation. Following surgery, men with seminomas may have radiation therapy to their abdominal lymph nodes. Nonseminomas are much less sensitive to radiation, so men with this type of cancer usually do not undergo radiation. Radiation therapy affects normal as well as cancerous cells.

The side effects of radiation therapy depend mainly on the treatment dose. Common side effects include fatigue, skin changes at the site where the treatment is given, loss of appetite, nausea, and diarrhea.


Chemotherapy is the use of drugs to kill cancer. Anticancer drugs are recommended when there are signs that the cancer has spread. These medications also are sometimes used when the doctor suspects that undetected cancer cells remain in the body after surgery or irradiation. This is known as adjuvant therapy.

Effects on Fertility

Many men worry that losing one testicle will affect their ability to have sexual intercourse or make them sterile. But a man with one healthy testicle can still have a normal erection, produce sperm, and father a child. Therefore, surgery to remove just one testicle does not make a patient impotent.

However, some treatments can affect a man's fertility. Radiation therapy interferes with sperm production, but most patients regain their fertility within a matter of months. Some anticancer drugs also interfere with sperm production. Although the reduction in sperm count is permanent for some patients, many others recover their fertility.

Also, surgery to remove the lymph nodes can cause infertility because it may interfere with the nerves involved in ejaculation. Some men may recover the ability to ejaculate without further treatment; others may be helped by medication. For many, though, it could be permanent. Men should talk to their doctor about a nerve-sparing surgical technique that may protect the ability to ejaculate.

Second Opinion

Getting a second opinion means asking a testicular cancer specialist, aside from your initial physician, to review your medical reports and test results and then provide a diagnosis and treatment recommendations. The specialist may confirm your initial diagnosis and treatment recommendations, provide additional treatment options, or even give more details about your type and stage of testicular cancer. Even if you’ve already had treatment, it’s not too late to get a second opinion. To get a second opinion contact our testicular cancer specialists by calling us at 877-715-HOPE.

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